Vilasrao Deshmukh passed away today at 1:30 pm in Chennai, according to reports.
Deshmukh, who was Union Minister for Science & Technology, had been diagnosed with liver cancer.
He was flown to Chennai's Global Hospital last week for a liver transplant, but went through multiple-organ failure. He was aged 67 years.
He was undergoing treatment at Breach Candy hospital in Mumbai for about a week and had to be shifted to Global hospitals, a super-speciality hospital in Chennai due to deterioration in his condition.
Both Houses of Parliament were adjourned for the day today, as a mark of respect to former Maharashtra chief minister Vilasrao Deshmukh.
President Pranab Mukherjee, PM Manmohan Singh and Congress President Sonia Gandhi condoled the death of Vilasrao Deshmukh.
President's Independence Day celebrations have been cancelled after Vilasrao Deshmukh's sad demise.
Vilasrao Deshmukh's funeral will take place in Babhalgaon village in Latur, according to reports.
The two-time Maharashtra Chief Minister was born in a family of landlords on May 26, 1945. He graduated with a degree in Science (B.Sc.) and Arts (B.A.) from M.E.S Abasaheb Garware College, (Pune University) and went on to study law (L.L.B.) from the ILS Law College (Pune University).