Broader indices BSE Midcap and BSE Smallcap outperformed the benchmark and ended the session on a flat note.
Barring healthcare and auto, all the other sectoral indices, namely capital goods, consumer durables, IT, and banking closed in the red.
Among global indices, both European and Asian markets traded lower.
On the economy front, WPI inflation for the month of May increased to a 14-month high of 4.43% from 3.18% in previous month.
Pharma stocks continued to gain for the seventh consecutive day and closed higher by 2% in Thursday’s trade.
Alembic Pharmaceuticals stock gained 3% after it received USFDA approval on its ANDA for Doxycycline Hyclate Capsules USP (50mg and 100mg).
Shares of ITDC hit the 20% upper circuit on heavy volumes. The scrip opened at Rs392 and touched a high and low of Rs465.05 and Rs387.70, respectively.
Cipla stock rose 1% after the pharma company received final USFDA approval for Isoproterenol HCL Injection USP, 0.2mg/mL. It is a generic equivalent version of Hospira’s Isuprel Injection.
Punj Lloyd stock slipped 11% after ICICI Bank dragged the company to NCLT and pleaded proceedings under the Insolvency & Bankruptcy Code (IBC), as per media reports.
Mindtree stock slipped 3.5% after Citi downgraded the stock to 'Sell' from 'Neutral'.
Top gainers and losers
Lupin (+3.6%), Sun Pharma (+2.4%), HCL Tech (+1.3%), Cipla (+1.3%), and Yes Bank (+0.99%) were the top gainers on the Nifty50.
Tech Mahindra (-2.2%), Adani Ports (2.1%), TCS (-2.1%), Indiabulls Housing Finance (-2.1%), and IOC (-2%) were the top losers.
Of the 2,059 stocks traded on Nifty, 787 advanced, 918 declined, and 354 remained unchanged.